- National Government and Law
- Diplomacy
- Military
- State/Local Government and Law
- Public Policy, Activism, and Philanthropy
- Business
- Medicine, Science, and Technology
- Education
- Literature
- Journalism and Media
- Fine Arts and Entertainment
- Athletics
National Government and Law

- David Addington (JD 1981) Chief of Staff to former Vice President Dick Cheney
- George Venable Allen (1924) Ass. Secretary of State for Public Affairs; US Ambassador to Iran and Yugoslavia
- Michael Bassett (PhD 1964) New Zealand Parliament
- Elizabeth Dole (DHL 2000, AB 1958) Commissioner of the FTC; US Secretary of Transportation; US Secretary of Labor; President of the American Red Cross; Senator NC
- Allyson Duncan (JD 1975) Judge, US Court of Appeals for the 4th Circuit
- Arkady Dvorkovich (PhD 1998) Chief Economic Advisor to Russian President Dmitry Medvedev
- Orinda Evans (AB 1965) US District Court Judge
- John P. Hannah (AB 1984) Assistant for National Security to former Vice President Dick Cheney
- Karen L. Henderson (AB 1966) US Court of Appeals
- Hashim bin Al Hussein (AB 2005) Prince of Jordan
- Susan Illston (AB 1970) Federal Judge
- John Koskinen (AB 1961) Deputy Director of the White House Office of Management and Budget; President, U.S. Soccer Foundation
- Juanita M. Kreps (LLD 1993, PhD 1948, AM 1944) US Secretary of Commerce 1977-1979; Professor; Economist
- Ricardo Lagos (LLD 2005; PhD 1966, AM 1963) Former President of the Republic of Chile
- Reggie Love (AB 2005) Personal Aide to President Barack H. Obama
- Kevin J. Martin (MPP 1993) Chairman of the Federal Communications Commission
- Amit Mitra (AM 1976, PhD 1978) Secretary General of the Federation of Indian Chambers of Commerce & Industry, Winner of India's National Civilian Award Padma Shree
- Richard Nixon (LLB 1937) 37th President of the United States
- Ron Paul (MD 1961) Presidential candidate 1988 and 2008; Congressman TX
- Robert Macon Phillips (AB 2000) White House Director of New Media
- Daniel Calhoun Roper (1888) US Secretary of Commerce under Franklin Delano Roosevelt
- Robert Sheheen (AB 1965) Speaker, House of Representatives
- Eric Shinseki (AM 1976) US Secretary of Veterans Affairs; US Army Chief of Staff
- Doug Sosnik (AB 1979) Senior Advisor and Political Director to Former President Bill Clinton
- Kenneth Starr (JD 1973) US Solicitor General; Independent Counsel during the Whitewater Affair
- Daniel Tarullo (AM 1974) Nominated to Board of Governors of the Federal Reserve by Barack Obama
- Elizabeth Verville (AB 1961) Deputy Assistant Secretary of State for Political and Military Affairs
- Jared Weinstein (AB 2002) Personal Assistant to George W. Bush
- Jeffrey Zients (AB 1988) US Chief Performance Officer
- Catherine Zoi (BS 1983) Chief of Staff of the White House on Environmental Policy; CEO of Al Gore's Alliance for Climate Protection
Diplomacy

- George Venable Allen (1924) Ass. Secretary of State for Public Affairs; US Ambassador to Iran and Yugoslavia
- Robert Sherwood Dillon (AB 1951) US Ambassador to Lebanon
- William Eacho (AB 1976) US Ambassador to Austria
- Robert C. Frasure (PhD 1970) US Ambassador to Estonia
- Gordon D. Giffin (AB 1971) US Ambassador to Canada
- Jack Gosnell (BS 1966) US Consul General St. Petersburg, Russia
- Richard W. Graber (AB 1978) US Ambassador to Czech Republic
- Robert Jordan (BA 1967) US Ambassador to Saudi Arabia
- Bob Krueger (AM 1959) Senator and Representative TX; US Ambassador to Burundi
- Philip Lader (AB 1966) US Ambassador to the UK
- Jack F. Matlock, Jr. (AB 1950) US Ambassador to Czechoslovakia and the Soviet Union
- Walter P. McConaughy (1930) US Ambassador to Burma, South Korea, Pakistan, and Taiwan
Military

- William Atwater (PhD 1987, MA 1981) Captain US Marines; Author; Historian; Director US Army Ordinance Museum
- General Walter Boomer (AB 1960) Major General, Retired; Assistant Commandant, USMC; Desert Storm Commander
- Admiral Frank Bowman (DHL 2003, AB 1966) Admiral US Navy, Retired; Chief of Naval Personnel, Director of Naval Nuclear Propulsion, US Navy
- Winston Choo (MA 1892) Lieutenant-General, Retired; Chief of Defense Force Singapore Armed Forces
- Commander Edward Deets (AB 1979) Rear Admiral US Navy
- Charles S. Hamilton (BS 1974) Rear Admiral US Navy
- James W. Holsinger (PhD 1968, MD 1964) Major General US Army Reserve; Physician nominated to become 18th Surgeon General of US
- Ng Jui Ping (MA) Lieutenant-General, Retired; Chief of Defence, Singapore Armed Forces
- Eric Shinseki (AM 1976) US Secretary of Veterans Affairs; US Army Chief of Staff
- Kevin R. Slates (MBA) Rear Admiral US Navy
State/Local Government and Law

- Hugh Quincy Alexander (1936, 1933) Representative NC
- Austin M. Allran (AB 1974) Senator NC
- Robert Franklin Armfield 1853 Congressman NC; Lieutenant Governor NC
- Ed Austin Mayor of Jacksonville, FL
- Daniel T. Blue, Jr. (JD 1973) Senator NC
- F. Vernon Boozer (AB 1958) Senator MD
- Scott Brister (AB 1977) Chief Justice, TX Supreme Court
- Maurice G. Burnside (PhD 1938) Congressman WV
- Bill Campbell (JD 1977) Mayor of Atlanta, GA
- Cason Carter (AB 2000) City Council Tulsa, OK
- R. Gregg Cherry (1912) Governor NC
- Robert L. Clifford (LLB 1950) Associate Justice, NJ Supreme Court
- Jack Conway (AB 1991) Attorney General KY
- Ann Covington (AB 1963) Chief Justice, MO Supreme Court
- J. Kane Ditto (AB 1966) Mayor Jackson, MS
- Christine M. Durham (JD 1971) Chief Justice, UT Supreme Court
- J.B. Fuqua Chairman GA Democratic Party; Chairman Fuqua Companies and Fuqua Enterprises
- Nick Galifianakis (LLB 1953, AB 1951) Representative NC
- Lisa Gladden (AB 1986) Representative MD
- Hannibal Lafayette Godwin (1897) Representative NC
- Thomas Grady (JD 1982) Representative FL
- Robert Hayes (AB 1967) Congressman NC's 8th district
- Paul B. Henry (PhD 1970, AM 1968) Representative MI
- Henry Hyde Representative IL
- Robert D. Inglis (AB 1981) Representative SC
- Ted Kaufman (BSME 1960) Senator DE
- Bob Krueger (AM 1959) Senator and Representative TX; US Ambassador to Burundi
- Chris Lauzen (AB 1974) Senator IL
- Jeffrey Lichtman (JD 1990) Defense Attorney for John Gotti, Fat Joe, and The Game
- Dan Lipinski (PhD 1998) Congressman IL's 3rd district
- Stan Lundine (AB 1961) Congressman NY
- Denise Majette (JD 1979) GA state judge; US Representative GA
- Evelyn Murphy (PhD 1965, AB 1961) Governor MA
- Paul Martin Newby (AB 1977) Associate Justice, NC Supreme Court
- Lee Slater Overman (1874) Senator NC
- Susan Owens (AB 1971) Associate Justice, WA Supreme Court
- Ron Paul (MD 1961) Representative TX; 2008 Republican Presidential candidate
- Enrique Penalosa (AB 1977) Mayor of Bogota, Colombia
- Nick Rahall (AB 1971) Congressman WV
- Eric Rothschild (AB 1989) Lead Attorney for Kitzmiller v. Dover Area School District
- Robert Sheheen (AB 1965) Speaker SC House of Representatives
- Willis Smith (1910) Senator NC; US observer at Nuremberg Trials
- Lura S. Tally (AB 1942) NC House of Representatives; US Senator NC
- William B. Umstead (1921) Governor NC
- Don Willett (MA 1992, JD 1992) Associate Justice, TX Supreme Court
- Bob Wise (AB 1970) Governor WV
Public Policy, Activism, and Philanthropy

- John H. Adams (LLD 2005, LLB 1962) Co-Founder, Natural Resources Defense Council
- Gregory Baylor (JD 1990) Religious activist, Christian Legal Society
- Charlotte Bunch (AB 1966) Author; Human rights activist
- Benjamin Chavis, Jr. (MDIV 1980) Civil rights activist; Executive Director of NAACP
- Mary Duke Biddle (1907) Daughter of Benjamin Newton and Sarah Pearson Angier Duke; Founder, Mary Duke Biddle Foundation
- Melinda French Gates (MBA 1987, BS 1986) Co-Founder, Bill and Melinda Gates Foundation
- Neal Keny-Guyer (AB 1976) CEO, Mercy Corps
- Mary Duke Biddle Trent Semans (LLD 1983, AB 1939) Philanthropist
- Eleanor Smeal (LLD 1991, AB 1961) Political activist; President, Feminist Foundation; President, National Organization for Women
Business

- Rex Adams (AB 1962) Chairman, PBS; VP, Mobil Corporation
- Harsha Agadi (MBA 1987) Chairman and CEO, Friendly Ice Cream Corporation; President and CEO, Church's Chicken
- John A. Allison IV (MBA 1974) Chairman and CEO, BB&T
- John Angelos (AB 1989) Executive VP, Baltimore Orioles
- Steven Black (AB 1974) Vice Chairman, JP Morgan Chase & Co.
- Roy J . Bostock (AB 1962) Chairman, Sealedge Investments, LLC; Chairman of BICom3 Group, Inc.; Board of directors for Morgan Stanley, Yahoo, and Northwest Airlines
- Jack O. Bovender Jr. (MHA 1969, AB 1967) Chairman and CEO, HCA
- Andrew Busey (AB 1993) Creator of ichat
- Lewis B. Campbell (BSME 1968) CEO, Textron, Inc.
- John Canning, Jr. (JD 1969) President, Madison Dearborn Partners; Co-owner, Milwaukee Brewers
- John Chambers Chairman and CEO, Cisco Systems
- Robert L. Cook (BS 1973) Oscar-winning software-programmer; VP of Advanced Technology, Pixar Animation Studios
- Timothy D. Cook (MBA 1988) COO and CEO, Apple Inc.
- Bradley J. Dodson (AB 1996) VP, CFO, and Treasurer, Oil States International
- Jim Ellis Co-creator of Usenet with Tom Truscott
- Nola Maddox Falcone (AB 1961) Managing Principal, NMF Asset Management, LLC
- Clay Felker (DHL 1998, AB 1951) Founding Editor of NY Magazine
- Michael Q. Fellmeth (AB 1992) VP, Dramatists Play Service
- Danny Ferry (AB 1989) General Manager, Cleveland Cavaliers
- Thomas Finke (MBA 1991) Chairman and CEO, Babson Capitol Management
- Michael J. Fitzpatrick (AB 1970) Chairman and CEO, E-Trek Dynamics
- J.B. Fuqua Chairman of the Board, Fuqua Companies; Founder, J.B. Fuqua Foundation; Namesake of Duke's Fuqua School of Business
- Melinda French Gates (MBA 1987, BS 1986) Co-founder, Bill and Melinda Gates Foundation
- David R. Goode (AB 1962) Chairman, President, and CEO, Norfolk Southern
- William H. Gross (AB 1966) CIO and Managing Officer, PIMCO
- Scott Guthrie (AB 1997) Product Unit Manager, Microsoft
- Hank Halter (MBA 1993) CFO, Delta Airlines
- William A. Hawkins (BSE 1976) CEO, Medtronic
- Betsy Holden (AB 1977) CEO, Kraft Foods
- Beth Hubbard (AB 1985) President, Gotham Entertainment Production Co.
- W. Bruce Johnson (MBA 1977, JD 1977, AB 1973) Interim CEO and President, Sears Holdings Corporation
- Edwin L. Jones, Jr. (BSCE 1948) Engineer and President, J. A. Jones Construction Company
- Bruce Karsh (AB 1977) Co-Founder and President, Oaktree Capital Management
- Timothy Kasbe (MBA 2000) CIO, Sears Holdings Corporation
- Neal Keny -Guyer (AB 1976) CEO, Mercy Corps
- Jeffrey Kip (MBA 1999) CFO, Panera Bread
- Richard Kirkland (AM 1976) S/B Managing Editor, Fortune Magazine
- Eric Kirsten (AB 1991) Founder and President, Fantzer, Inc. and Coolspotters.com; Board member for Sara Happ Cosmetics
- John A Koskinen (AB 1961) Deputy Director, Office of Management and Budget; President, US Soccer Foundation
- Mike Lamach (MBA 2001) President and COO, Ingersoll Rand
- Dylan Lauren (AB 1996) President and Founder, Dylan's Candy Bar
- J. Richard Leaman III (MBA 1986, AB 1984) Managing Director, Moelis & Company; Joint Global Head of Investment Banking, UBS
- Dan Levitan (AB 1979) Co-Founder and Managing Director Maveron LLC
- Diane Britz Lotti (AB 1974) Managing Director, Circle Financial Group
- Gerard Louis-Dreyfus (LLB 1957, AB 1955) Owner, Louis-Dreyfus Family Office LLC
- John J. Mack (AB 1968) CEO, Morgan Stanley; CEO, Credit Suisse First Boston
- Aubrey McClendon (AB 1981) CEO, Chairman, and Co-Founder, Chesapeake Energy; Shares ownership of the Oklahoma City Thunder
- Sean McManus (AB 1977) President, CBS News and CBS Sports
- Lalit Modi (1986) President and Managing Director, Modi Enterprises; Chairman and Founder, Indian Premier League
- Raymond Nasher (AB 1943) Real Estate Developer; Philanthropist; Namesake of Duke's Nasher Museum of Art
- Peter Nicholas (AB 1964) Co-Founder and Chairman, Boston Scientific Corporation
- Stephen Pagliuca (BA 1977) Managing Director of Bain Capital; Shares ownership of of the Boston Celtics
- Edmund T. Pratt, Jr. (BSEE 1947) CEO of Pfizer; Philanthropist; Namesake of Duke's Edmund T. Pratt School of Engineering
- Mark Rosenbaum (MBA 1987) CFO, MySpace
- Drew Rosenhaus (JD 1990) CEO, Rosenhaus Sports Representation
- David M. Rubenstein (AB 1970) Co-Founder and Managing Director, The Carlyle Group; Namesake of Duke's Rubenstein Hall
- Monty Sarhan (JD 1999) VP, MTV Networks / Viacom; Publisher and CEO, Cracked
- W. Russel Scheirman (MS 1978, BSE 1977) President and COO, Vaalco Energy Inc.
- Alan Schwartz (AB 1972) Executive Chairman, Guggenheim Partners, LLC; CEO, Bear Sterns
- Bobby Sharma (JD 1998, AB 1995) VP & General Counsel, NBA Development League
- Adam Silver (AB 1984) Deputy Commissioner and COO, NBA
- Christopher L. Smith (AB 1990) President, Transit Systems, Inc.
- Sam A. Solomon (MBA 1992) President and CEO, The Coleman Company
- W. David Stedman (AB 1942) Chairman, Stedman Associates
- Robert K. Steel (AB 1973) Deputy Mayor of Economic Development, NYC-Office of the Mayor; President and CEO, Wachovia; Chairman of the Duke University Board of Trustees
- Terry Thompson (MBA 1999) COO, Mercer
- Bill Timmerman (AB 1968) Chairman, President, and CEO, SCANA
- Tom Truscott (AM 1981, BS 1975) Co-Creator of Usenet with Jim Ellis
- James L. Vincent (BSME 1961) Chairman and CEO, Biogen Inc.
- Jeffrey Vinik (BSCE 1981) Chairman, President, and CEO, Vinik Asset Management; Owner of the Tampa Bay Lightning
- Karl von der Heyden (AB 1962) Vice Chairman and CFO, PepsiCo, Inc.; Namesake Duke's von der Heyden Pavilion
- G. Richard Wagoner, Jr. (AB 1975) Chairman and CEO, General Motors Corporation
- Pamela J. White (MBA 1988) Executive VP and CFO, Express; CFO, Victoria's Secret
- Gary L. Wilson (AB 1962) Director, The Walt Disney Company; Co-Chairman, Northwest Airlines; Namesake of Duke's Wilson Recreation Center
- Gao Xiqing (JD 1986) General Manager and CIO, China Investment Corporation
- Harold "Spike" Yoh (BSME 1958) Chairman and CEO, Day and Zimmerman; Namesake of Duke's Yoh Football Center
Medicine, Science, and Technology

- David H. Adams (MD 1983, BS 1979) Specialist in heart valve surgery and mitral valve repair
- Eben Alsberg (BSE 1995) Tissue Engineer; Assistant Professor of Biomedical Engineer and Orthopaedic Surgery, Case Western Reserve University
- Lenox D Baker (MD 1934) Physician; Public Servant
- Ian Barbour (AM 1947) Physicist; Theologian; Recipient of the Templeton Prize in 1999
- Charles E. Brady, Jr. (MD 1975) Astronaut
- Fred Brooks (AB 1953) Engineer; Developer of OS/360; Turing Award winner
- John Cocke (DS 1988, PhD 1956, BSME 1945) Considered the father of the RISC computer architecture; IBM Fellow
- Richard Cytowic (AB 1973) Neuroscientist; Leading authority in the field of synesthesia; President, Capital Neurology
- Hans Dehmelt (Post-Doc. 1952-55) 1989 Nobel Laureate in physics; Co-developed the ion trap technique with Wolfgang Paul
- William DeVries (HS 1979, HS 1975) Pioneer of artificial organs; Academic Coordinator, Walter Reed Army Med. Center
- Sylvia Earle (DS 1993, PhD 1966, AM 1956) Marine biologist; Chief Scientific of the NOAA; CEO, Deep Ocean Exploration & Research
- Jim Ellis Co-creator of Usenet with Tom Truscott
- Paul Farmer (AB 1982) Infectious disease doctor; Winner of MacArthur Award; Subject of Pulitzer prize winner Tracy Kidder's biography Mountains Beyond Mountains
- Ken Gergen (PhD 1963) Notable American psychologist; Professor at Swarthmore College
- Jeffrey W. Holcombe (AB 1973) Moss specialist; Biology professor at The Loomis Chaffee School
- John M. MacDougal (PhD 1984) Botanist
- Robert L. Morris (PhD 1969) Notable psychologist; Koestler professor at the University of Edinburgh
- George Porter lll (HS 1959, MD 1958, AB 1954) President Emeritus, Ochsner Medical Foundation
- Robert C. Richardson (PhD 1966) 1966 Nobel Laureate in physics; F.R. Newman Professor of Physics at Cornell University
- Jim Scheinman (BS 1988) Co-Founder of Bebo; Early Friendster Employee; Came close to acquiring Facebook when it was in its infancy
- Dorothy Simpson (AB 1946) Scientist; Mathematician
- Dylan Smith (BS 2008) Founder and CFO, Box.net Inc.
- William Kennedy Smith Founder, Physicians Against Land Mines
- Henrique Tono (PhD 2007) Co-founder, Ingrain Inc.
- Charles H. Townes (DS 1966, AM 1937) 1964 Nobel Laureate in physics; Professor of physics at UC-Berkeley
- Tom Truscott (AM 1981, BS 1975) Co-Creator of Usenet with Jim Ellis
- Luis von Ahn (BS 2000) Inventor of the captcha and Google image labeler
- Olaf von Ramm (PhD 1973) First patent on a 3-D ultrasound; Developed first electronically steered matrix-array 3-D ultrasound imager; Professor at Duke
- F. Thomas Wooten, III (PhD 1964, BSEE 1957) President, Research Triangle Institute
Education

- Susan Athey (DS 2009, AB 1991) Professor of economics at Harvard University; Winner of the John Bates Clark Medal
- Dan Ariely (PhD 1998) Professor of behavioral economics at Duke; Head of the eRationality research group at the MIT Media Lab; Author of "Predictably Irrational"
- George Brumley, Jr. (HS 1961, HS 1960, MD 1960, AB 1956) Chairman of Pediatrics, Associate Dean, Emory University
- Fred Chappell (AM 1964, AB 1961) North Carolina Poet Laureate, Novelist
- Mauri Ditzler (PhD 1979) President Monmouth College
- David L. Downie (AB 1983) Author; Professor of Politics and Environment Policy at Fairfield University
- David Efird (AB 1994) Philosopher and lecturer at the University of York
- Lorenz Eitner (AB 1940) Renowned art historian
- Thomas Eugene Flanagan (PhD 1970, AM 1967) Conservative Canadian political scientist
- W. Kent Fuchs (BSE 1977) Provost of Cornell University
- Pamela Gann (JD 1973) President of Claremont McKenna College; Dean of Duke University School of Law
- Ken Gergen (PhD 1963) Notable American psychologist; Professor at Swarthmore College
- Douglas Hodgkin (PhD 1966, AM 1963) Political scientist; Author and professor at Bates College
- Josephine Humphreys (LITTD 1994, AB 1967) Award-Winning Novelist
- Frank Lentricchia (PhD 1966, AM 1963) Literary critic; Professor of literature at Duke University
- Theodore E. Long (AM 1968) President of Elizabethtown College
- A.D. Kirwan (1947) President of the University of Kentucky
- Juanita M. Kreps (LLD 1993, PhD 1948, AM 1944) US Secretary of Commerce 1977-1979; Professor; Economist
- Benjamin Ladner (PhD 1971) President of American University
- Peter Maas (AB 1950) Author of novels The Valachi Papers and Serpico
- Robert L. Morris (PhD 1969) Notable psychologist; Koestler professor at the University of Edinburgh
- Reynolds Price (AB 1955) Renowned author and professor of literature at Duke University
- David P. Roselle (PhD 1965) President of the University of Delaware
- Haun Saussy (AMB 1981) Bird White Housum Professor of Comparative and Chinese literature at Yale
- Margaret Taylor Smith (AB 1947) Author; Social activist; Chair Kresger Foundation
- William C. Styron (DLETT 1968, AB 1947) Author, Pulitzer Prize Winner
- David E. Sweet (PhD 1968) Founding President of Metropolitan State University; President of Rhode Island College
- Jill Tiefenthaler (PhD 1951) Provost of Wake Forest University
- Anne Tyler (AB 1961) Pulitzer Prize-winning novelist and writer of short stories
- F. Thomas Wooten lll (PhD 1964, BSEE 1957) President of the Research Triangle Institute
- Theodore Ziolkowski (AM 1952, AB 1951) Dean of the Graduate School, Princeton University
Literature

- James Armstrong (MBA 2006, BS 1982) Author of "UNIX Secrets" and other computer books
- Fred Chappell (AM 1964, AB 1961) North Carolina Poet Laureate; Novelist
- Guy Davenport (AB 1948) Author "Thasos and Ohio"; National Review contributor
- Lee McGeorge Durrell (PhD 1979) Author; Television presenter; Zookeeper
- Josephine Humphreys (LITTD 1994, AB 1967) Award-winning Novelist
- Mac Hyman (AB 1947) Author of "No Time for Sergeants"
- Russell Kirk (AM 1941) Author of "The Conservative Mind"
- Nathaniel Lande (AB 1956) Author; Filmmaker; Creative director, TIME
- Peter Maas (AB 1950) Author of novels "The Valachi Papers" and "Serpico"
- Lydia Millet (MEM 1996) Author of "Oh Pure and Radiant Heart", "Everyone's Pretty", and other novels
- Noel Perrin (AM 1950) Scholar; Essayist; Critic; Professor at Dartmouth College
- Reynolds Price (AB 1955) Renowned author; James B. Duke professor of literature at Duke
- Lynn Veach Sadler (AB 1962) Poet; Author; Playwright
- Haun Saussy (AB 1981) Bird White Housum Professor of Comparative and Chinese literature at Yale
- Margaret Taylor Smith (AB 1947) Author; Social activist; Chair Kresger Foundation
- William C. Styron (DLETT 1968) Author; Pulitzer Prize winner
- Anne Tyler (AB 1961) Pulitzer Prize-winning novelist and writer of short stories
- Dana Vachon (AB 2002) Author of "Mergers & Acquisitions"
- Haim Watzman (AB 1978) Writer
- Richard Zimler (AB 1977) Novelist; Author of "The Last Kabbalist of Lisbon"
Journalism and Media

- Dan Abrams (AB 1988) Chief Legal Analyst for NBC News; General Manager of MSNBC; CEO of Abrams Research
- Dan Bernstein (AB 1991) Sports journalist; WSCR radio host
- Jay Bilas (JD 1992, AB 1986) Sports analyst, ESPN
- Jessica Faye Carter (JD 2002, MBA 2002) Author; Columnist; Social media entrepreneur
- John Feinstein (AB 1977) Writer, The Washington Post Company; Sports journalist
- Clay Felker (DHL 1998, AB 1951) Founding Editor of NY Magazine
- Sean Flynn Actor; Vietnam War photojournalist
- Mike Gminski (AB 1980) Sports Commentator, ESPN
- David Hartman (AB 1956) First host of Good Morning America on ABC
- Mangesh Hattikudur (AB 2001) Co-founder of Mental Floss with Will Pearson
- John Harwood (AB 1978) Political writer for The New York Times; National Political Editor for The Wall Street Journal; Frequent panelist on Washington Week
- Rik Kirkland (AM 1976) Director of Publishing, McKinsey & Company
- Scott McCartney (AB 1982) Travel Editor and journalist for The Wall Street Journal; Author
- Sean McManus (AB 1977) President, CBS News and CBS Sports
- Susannah Meadows (AB 1995) Senior Writer for Newsweek
- Will Pearson (AB 2001) Co-founder of Mental Floss with Mangesh Hattikudur
- Charlie Rose (JD 1968, AB 1964) Journalist; CBS News Anchor; 60 Minutes contributor; The Charlie Rose Show
- Jim Rosenfield (AB 1981) WCBS-TV anchor
- John Seigenthaler, Jr. (AB 1978) NBC and MSNBC news anchor; Partner and CEO of New York Operations, Seigenthaler Public Relations
- Kathy Deane (AB 1978) President, Tobe Report
- Elizabeth Spiers (AB 1999) Columnist, Fortune Magazine; Founding editor of Gawker.com
- Judy Woodruff (DHL 1998, AB 1968) NBC's White House correspondent; Washington correspondent for the MacNeil/Lehrer NewsHour; Anchor at CNN
Fine Arts and Entertainment

- Lt. Andy Baldwin (BS 1999) The Bachelor; Lieutenant; Physician and Diver, United States Navy
- Michael Best (AB 1962) Principal Artist of the Metropolitan Opera
- Jayne Brook (AB 1982) Actress, Chicago Home
- Les Brown (1936) Musician, Les Brown and The Band of Renown; Jazz Hall of Fame Inductee 1999
- Ryan Carnes (2004) Actor Desperate Housewives, Eating Out
- Michael Ching (AB 1980) Composer, Memphis Opera
- Jack Coleman (AB 1980) Actor, Heroes, Dynasty, Days of our Lives
- Robert L. Cook (BS 1973) Oscar-winning software-programmer; VP of Advanced Technology, Pixar Animation Studios
- Bill Cunliffe (AB 1978) Grammy Award-winning composer; Arranger, Pianist
- Kara DioGuardi (AB 1993) American Idol judge; Songwriter for musicians including Carlos Santana, Kelly Clarkson, and Britney Spears
- Lee McGeorge Durrell (PhD 1979) Author; Television presenter; Zookeeper
- Rene Echevarria (AB 1984) Producer, The 4400, Dark Angel, Now and Again; screenwriter, Star Trek: The Next Generation, Star Trek: Deep Space Nine
- Michael Q. Fellmeth (AB 1992) VP, Dramatists Play Service
- Sean Flynn Actor; Vietnam War photojournalist
- Annabeth Gish (AB 1993) Actress, X-Files, The West Wing
- Kelly Goldsmith (AB 2001) Actress, Survivor
- Kevin Gray (AB 1980) Broadway actor, Phantom on Broadway after Michael Crawford
- John Gromada (AB 1986) Broadway composer and sound designer
- Beth Hubbard (AB 1985) Co-Founder, Bright Idea Entertainment, LLC; President, Gotham Entertainment Production Co.
- David Hudgins (AB 1987) Television writer and producer, Everwood, Friday Night Lights
- Kevin Isola (AB 1992) Broadway actor, Brooklyn Boy
- Martin Kratt (BS 1989) Creator and star of PBS's Zoboomafoo
- Adam Lord (AB 2003) Musician; writer
- Bruce Lund (BS 1973) Toy designer; President/Founder Lund & Company Invention LLC
- Peter Maas (AB 1950) Author of novels The Valachi Papers and Serpico (later made in movies)
- Jon Marans (AB 1979) Playwright, Old Wicked Songs, The Temperamentals
- Ben Mulroney (AB 1997) Host of Canadian Idol and eTalk Daily
- Andrea Nelson Meigs (JD 1994) Talent agent, International Creative Management
- Vanessa Rousso (AB 2003) Professional poker player
- Mike Posner (AB 2009) Musician
- Adam Sampieri (AB 2003) Musician, Writer
- Monty Sarhan (JD 1999) Vice President, MTV Networks / Viacom; Publisher and CEO, Cracked
- Rebecca Sealfon (MS 2008) Winner of 1998 Scripps National Spelling Bee; Internet celebrity
- Retta (AB 1992) Stand-up comedian and actress, Parks and Recreation
- Ryan Senft (BS 2002) Musician
- William Stone (AB 1966) Operatic baritone
- Travis Lane Stork (AB 1994) Reality star of ABC's Bachelor 8
- Jim Toomey (MEM 2008, BSE 1983) Syndicated cartoonist of Sherman's Lagoon
- Randall Wallace (AB 1971) Author of the screenplays for Braveheart, The Man in the Iron Mask, Pearl Harbor, and We Were Soldiers
- Patrick Williams (AB 1961) Composer for movies and TV, Emmy and Grammy winner
- Robert Yeoman (AB 1973) Cinematographer for films Bottle Rocket, Rushmore, The Royal Tenenbaums, the Life Aquatic with Steve Zissou, and The Darjeeling Limited
Athletics (Current professional athletes denotated by "*")

Baseball
- Wayne Ambler (AB 1937) MLB, Philadelphia Athletics
- Bob Brower (AB 1982) MLB, New York Yankees
- Chris Capuano* (BS 2000) MLB, Free agent
- Lawrence "Crash" Davis (AB 1940) MLB, Philadelphia Athletics; Inspiration for the main character of the 1988 movie Bull Durham
- Dick Groat (AB 1953) MLB, Pittsburgh Pirates and St. Louis Cardinals; NBA
- Ryan Jackson (AB 2006) MLB, Detroit Tigers; Coach of men's baseball at Duke
- Bill McCahan (AB 1942) MLB, Philadelphia Athletics
- Quinton McCracken (AB 1992) MLB; Member of 2001 World Series Champion Arizona Diamondbacks
- Clarence "Ace" Parker (1937) MLB, Philadelphia Athletics; NFL, Brooklyn Dodgers; Hall of Fame 1972
- Scott Schoeneweis* (AB 1996) MLB; Free agent; Member of 2002 World Series Champion Anaheim Angels
- Al Spangler (AB 1956) MLB, Milwaukee Braves
- Eric Tipton (AB 1939) MLB, Cincinnati Reds
- Mike Trombley (AB 1990) MLB, Minnesota Twins
- Hal Wagner (1938) MLB, Boston Red Sox
Basketball
- Tommy Amaker (MBA 1989, AB 1987) Head coach of men's basketball at Harvard, University of Michigan, and Seton Hall University; Assistant coach at Duke
- Alison Bales* (AB 2007) WNBA, Atlanta Dream
- Shane Battier* (AB 2001) NBA, Houston Rockets; Duke jersey retired
- Alana Beard* (AB 2004) WNBA, Washington Mystics; Duke jersey retired
- Chante Black* (AB 2009) WNBA, Tulsa Shock
- Carlos Boozer* NBA, Chicago Bulls; Olympic bronze at 2004 Summer Olympics and Olympic gold at 2008 Summer Olympics
- Elton Brand* NBA, Philadelphia 76ers
- Jeff Capel (AB 1997) USBL, Raleigh Cougars; Head coach of men's basketball at University of Oklahoma
- Chris Collins (AB 1996) Assistant coach of men's basketball at Duke
- Monique Currie* (AB 2005) WNBA, Washington Mystics
- Johnny Dawkins (AB 1986) Head coach of men's basketball at Stanford University; Associate coach at Duke; NBA, Detroit Pistons; Duke jersey retired
- Luol Deng* NBA, Chicago Bulls
- Charles "Lefty" Driesell (AB 1954) College basketball coach
- Chris Duhon* (AB 2004) NBA, Orlando Magic
- Mike Dunleavy, Jr.* (AB 2005) NBA, Indiana Pacers
- Danny Ferry (AB 1989) GM of the San Antonio Spurs; NBA; Member of 2003 NBA Champion San Antonio Spurs; Duke jersey retired
- Mike Gminski (AB 1980) CBS sports analyst; NBA, New Jersey Nets; Duke jersey retired
- Dick Groat (AB 1953) MLB, Pittsburgh Pirates and St. Louis Cardinals; NBA
- Lindsey Harding* (AB 2007) WNBA, Washington Mystics
- Art Heyman (AB 1963) NBA, New York Knicks; Duke jersey retired
- Grant Hill* (AB 1994) NBA All-Star, Phoenix Suns; Duke jersey retired
- Bobby Hurley (AB 1993) NBA, Sacramento Kings; Duke jersey retired
- Dahntay Jones* (AB 2003) NBA, Indiana Pacers
- Billy King (AB 1988) GM of the New Jersey Nets
- Christian Laettner (AB 1992) NBA, Miami Heat; Only college player on 1992 Olympic gold "Dream Team;" Duke jersey retired
- Corey Maggette* NBA, Milwaukee Bucks
- Josh McRoberts* NBA, Indiana Pacers
- Jeff Mullins (AB 1964) Head men's basketball Coach at UNC Charlotte; NBA, Golden State Warriors; Duke jersey retired
- Shavlik Randolph* NBA, Miami Heat
- J.J. Redick* (AB 2006) NBA, Orlando Magic; Was NCAA's all-time leader in three-point field goals; Duke jersey retired
- Bobby Sharma (JD 1998, AB 1995) VP & General Counsel, NBA Development League
- Adam Silver (AB 1984) Deputy Commissioner and COO, NBA
- Quin Snyder (JD 1995, MBA 1995, AB 1989) Developmental coach of the Philadelphia 76ers; Head coach of NBA Austin Toros; Head coach of men's basketball at the University of Missouri; Assistant coach at Duke
- Jim Spanarkel (AB 1979) Studio analyst for NBA TV; NBA, Dallas Mavericks
- Michele Van Gorp (AB 1999) WNBA, Minnesota Lynx
- Jason (Jay) Williams (AB 2002) NBA, Chicago Bulls; Duke jersey retired
- Shelden Williams* (AB 2006, CER 2006) NBA, Denver Nuggets; Duke jersey retired
- Steve Wojciechowski (AB 1998) Assistant coach of men's basketball at Duke
Football
- Patrick Bailey* (2007) NFL, Tennessee Titans
- Ryan Fowler* (AB 2004) NFL, New York Jets
- Sonny Jurgensen (AB 1957) NFL Washington Redskins; Hall of Fame quarterback
- Kevin Lewis (AB 2000) NFL, New York Giants
- Thad Lewis* (AB 2009) NFL, St. Louis Rams
- Patrick Mannelly* (1998) NFL, Chicago Bears
- George McAfee (1940) NFL, Chicago Bears; Hall of Fame halfback
- Scottie Montgomery (AB 2000) NFL, Oakland Raiders
- Ayanga Okpokowuruk* (AB 2009) NFL, New York Giants
- Ben Patrick* (AB 2006) NFL, Arizona Cardinals
- Clarence "Ace" Parker (1937) MLB, Philadelphia Athletics; NFL, Brooklyn Dodgers; Hall of Fame 1972
- Vincent Rey* (AB 2010) NFL, Cincinnati Bengals
- Drew Strojny* (AB 2003) NFL, Free agent; St. Louis Rams
Golf
- Stewart "Skip" Alexander (AB 1941) PGA; 3 PGA Tour wins
- Jean Bartholomew* (AB 1989) LPGA
- Beth Bauer (AB 2000) LPGA
- Amanda Blumenherst* (AB 2009) LPGA
- Jenny Chuasiriporn (AB 1999) LPGA
- Anna Grzebien* (AB 2007) LPGA
- Liz Janangelo (AB 2006) Professional Golf
- Brittany Lang LPGA
- Jennie Lee (AB 2009) Professional Golf
- Joe Ogilvie* (AB 1996) PGA; 1 PGA Tour win
- Mike Souchak PGA; 15 PGA Tour wins
- Kevin Streelman* (AB 2001) PGA
- Kristina Engstrom Tucker (AB 2003) Professional Golf
- Art Wall, Jr. (AB 1949) PGA; Winner of 1959 Masters Tournament; 14 PGA Tour wins
Other Athletic
- Kelly Bruno (BS 2005) Paralympian; Contestant on Survivor: Nicaragua
- Matt Danowski (AM 2009, AB 2007, CER 2007) Professional lacrosse player for New Jersey Pride; All-time leading points scorer in NCAA Lacrosse history; Tewaaraton Trophy winner in 2007; Two-time Jack Turnbull Award winner; Two-time Lt. Raymond Enners Award winner
- Paulie Harraka* Current Student NASCAR racer
- Jay Heaps (AB 1998) MLS
- Nancy Hogshead (AB 1986) Swimmer; 3 Olympic gold and 1 silver at the 1984 Summer Olympics
- Haley Ishimatsu Current Student Diver; 2008 US Olympic team in the 10-meter platform and the synchronized 10-meter platform
- Randy Jones (1991) Most decorated Olympic bobsledder in US history; First African-American to medal in Winter Olympics; Part of the United States Olympic Committee
- John Kerr, Jr. (AB 1987) Major League Soccer; Winner of Hermann Trophy for top collegian; Head coach of men's soccer at Harvard and Duke
- Jason Kreis (BS 1995) Major League Soccer
- Alison Levine (MBA 2000) Mountain climber and explorer; The only woman to have completed the Explorers Grand Slam
- Philip Schwalb (AB 1983) Founder of National Sports Museum of America
- Dave Sime (MD 1962, AB 1958) Olympic Silver Medalist in track; Held 7 World Records in track
- Andrew Skurka (AB 2003) 2007 National Geographic "Adventurer of the Year;" 2005 Backpacker Magazine "Person of the Year"
- Becca Ward Current Student Sabre Fencer; Gold at 2006 World Fencing Championships; 2 Olympic gold at 2008 Summer Olympics
